30494-27-0Relevant academic research and scientific papers
Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles
Milligan, John A.,Busacca, Carl A.,Senanayake, Chris H.,Wipf, Peter
supporting information, p. 4300 - 4303 (2016/10/30)
Hydrophosphination of bicyclo[1.1.0]butyl nitriles with phosphine boranes and phosphites provided novel cyclobutyl-P derivatives. The reaction generally favors the syn-diastereomer, and the nitrile can be reduced and converted to other functional groups, thus enabling the preparation of bidentate ligands that access new conformational space by virtue of their attachment to the torsionally malleable but sterically restrictive cyclobutane scaffold. The enantioselective hydrogenation of dehydrophenylalanine using a bidentate phosphine-phosphite ligand illustrates the synthetic utility of the newly prepared scaffold.
ADDITION TO BICYCLOBUTANE DERIVATIVES. V. ADDITION OF SODIUM METHANETHIOLATE AND THIOPHENOLATE TO 1-BICYCLOBUTANECARBONITRILE AND 3-METHYL- AND 3-PHENYL-1-BICYCLOBUTANECARBONITRILES
Razin, V. V.,Vasin, V. A.,Ogloblin, K. A.
, p. 836 - 840 (2007/10/02)
Sodium methanethiolate and thiophenolate add to unsubstituted 1-bicyclobutanecarbonitrile and also to its 3-methyl and 3-phenyl derivatives in a methanol medium exclusively at the central bicyclobutane C-C bond with nucleophilic attack at the β position t
