trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate

Base Information

• Chemical Name: trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate
• CAS No.: 867163-64-2
• Molecular Formula: C₁₄H₁₈ClN₃O₃
• Molecular Weight: 311.768
• Mol file: 867163-64-2.mol

Synonyms:trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate

Chemical Property of trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate

There total 3 articles about trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloropyrazin-2-yl)methylamine bis-hydrochloride (1332528-70-7) → trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate (867163-64-2)

Guidance literature:

4-(methoxycarbonyl)cyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 4h;

(3-chloropyrazin-2-yl)methylamine bis-hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃; for 20h;

Reference yield:

(3-chloropyrazin-2-yl)methylamine bis-hydrochloride (1332528-70-7) + 4-(methoxycarbonyl)cyclohexanecarboxylic acid (32529-79-6) → trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate (867163-64-2)

Guidance literature:

4-(methoxycarbonyl)cyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 4h;

(3-chloropyrazin-2-yl)methylamine bis-hydrochloride; With N-ethyl-N,N-diisopropylamine; at 20 - 60 ℃; for 20h;

Reference yield:

(3-chloro-pyrazin-2-yl)-methylamine (771581-15-8) + trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid (15177-67-0) → trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)-cyclohexanecarboxylate (867163-64-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2016.11.079

upstream raw materials:

(3-chloropyrazin-2-yl)methylamine bis-hydrochloride

4-(methoxycarbonyl)cyclohexanecarboxylic acid

(3-chloro-pyrazin-2-yl)-methylamine

trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid

Downstream raw materials:

trans-methyl 4-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclohexanecarboxylate