2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate:

Base Information

• Chemical Name: 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate:
• CAS No.: 1605274-95-0
• Molecular Formula: C₁₂H₆F₁₂O₄S
• Molecular Weight: 474.224
• Mol file: 1605274-95-0.mol

Synonyms:2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate:

Chemical Property of 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate:

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate:

There total 3 articles about 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate: which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + 4-(pentafluoro-λ6-sulfaneyl)benzenediazonium tetrafluoroborate (1605274-62-1) → 4-fluorobenzenesulfonyl fluoride (368-85-4) + 1-(pentafluorosulfanyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]benzene (1605274-93-8) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-fluorophenylsulfonate (141795-59-7) + 1-(fluorosulfonyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]-benzene (1605274-94-9) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate: (1605274-95-0)

Guidance literature:

at 60 ℃; for 4h;

DOI:10.1002/ejoc.201301538

Reference yield:

1,1,1,3',3',3'-hexafluoro-propanol (920-66-1) + 4-(pentafluoro-λ6-sulfaneyl)benzenediazonium tetrafluoroborate (1605274-62-1) → 4-fluorobenzenesulfonyl fluoride (368-85-4) + 1-(pentafluorosulfanyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]benzene (1605274-93-8) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-fluorophenylsulfonate (141795-59-7) + 1-(fluorosulfonyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]-benzene (1605274-94-9) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate: (1605274-95-0) + pentafluoro(4-fluorophenyl)-λ6-sulfane (1422-39-5,1063625-86-4)

Guidance literature:

at 60 ℃; for 3h;

DOI:10.1002/ejoc.201301538

Reference yield:

pentafluorosulfanylbenzene (2557-81-5) → 4-fluorobenzenesulfonyl fluoride (368-85-4) + 1-(pentafluorosulfanyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]benzene (1605274-93-8) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-fluorophenylsulfonate (141795-59-7) + 1-(fluorosulfonyl)-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]-benzene (1605274-94-9) + 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]phenylsulfonate: (1605274-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite; boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 °C / Cooling with ice

2: 4 h / 60 °C

With tert.-butylnitrite; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1002/ejoc.201301538

upstream raw materials:

1,1,1,3',3',3'-hexafluoro-propanol

4-(pentafluoro-λ⁶-sulfaneyl)benzenediazonium tetrafluoroborate

pentafluorosulfanylbenzene