N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Base Information

• Chemical Name: N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine
• CAS No.: 919530-66-8
• Molecular Formula: C₃₃H₅₄N₆O₅Si₂
• Molecular Weight: 671

Synonyms:N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property of N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

There total 4 articles about N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N2-isobutyryl-O6-benzyl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxy-guanosine (444594-35-8) → N2-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (919530-66-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo061803t

Reference yield:

p-toluidine (106-49-0,12221-03-3) → N2-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (919530-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₃PO₄; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxy-ethane / 50 h / 80 °C

2: 99 percent / hydrogen / Pd/C / methanol / 1 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane;

DOI:10.1021/jo061803t

Reference yield:

O6-benzyl-8-bromo-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (479408-22-5) → N2-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (919530-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / pyridine / 1 h / 20 °C

2: 75 percent / K₃PO₄; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxy-ethane / 50 h / 80 °C

3: 99 percent / hydrogen / Pd/C / methanol / 1 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In pyridine; methanol; 1,2-dimethoxyethane;

DOI:10.1021/jo061803t

upstream raw materials:

N²-isobutyryl-O⁶-benzyl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxy-guanosine

p-toluidine

O⁶-benzyl-8-bromo-3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

N²-iso-butyryl-O⁶-benzyl-8-bromo-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Downstream raw materials:

N²-isobutyryl-8N-(4-methylphenylamino)-2'-deoxyguanosine

N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 919530-66-8 N²-isobutyryl-8N-(4-methylphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send