methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

Base Information

Chemical Name:methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate
CAS No.:1621255-92-2
Molecular Formula:C₂₂H₂₄BF₃O₅
Molecular Weight:436.236
Hs Code.:

Synonyms:methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

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Chemical Property of methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

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Technology Process of methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

There total 4 articles about methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.6%

: 1621255-91-1
methyl 3'-iodo-4'-methoxy-2-(trifluoromethyl)biphenyl-4-carboxylate

: 73183-34-3
bis(pinacol)diborane

: 1621255-92-2
methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dimethyl sulfoxide; at 80 ℃; for 8h;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1621255-92-2
methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C

2: silver sulfate; iodine / methanol / 2 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / dimethyl sulfoxide / 8 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iodine; sodium carbonate; silver sulfate; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;

Reference yield:

: 1621255-90-0
methyl 4'-methoxy-2-(trifluoromethyl)biphenyl-4-carboxylate

: 1621255-92-2
methyl 4'-methoxy-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)biphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: silver sulfate; iodine / methanol / 2 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / dimethyl sulfoxide / 8 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iodine; sodium carbonate; silver sulfate; In methanol; dimethyl sulfoxide;