1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

Base Information

Chemical Name:1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt
CAS No.:357425-93-5
Molecular Formula:C₇H₈O₃S*C₁₁H₁₃N
Molecular Weight:331.436
Hs Code.:

Synonyms:1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

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Chemical Property of 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

There total 15 articles about 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 104-15-4
toluene-4-sulfonic acid

: 357426-13-2
1,5-methano-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine

: 357425-93-5
1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

Guidance literature:: 1,5-methano-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine; With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran;

toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1021/ol049316s

Reference yield:

: 104-15-4
toluene-4-sulfonic acid

: 230615-48-2
3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine

: 357425-93-5
1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 40 ℃; for 15h; under 2585.74 Torr;
DOI:10.1055/s-2004-829135

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 357425-93-5
1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / P(Cy)3; t-BuONa / Pd(OAc)2 / 1,2-dimethoxy-ethane / 22 h / 60 °C

2.1: H₂; H₂SO₄ / Pd/C / methanol

2.2: t-BuONa / propan-2-ol

3.1: NaBH₄; BF₃*OEt₂ / tetrahydrofuran

3.2: 81 percent / tetrahydrofuran

With sodium tetrahydroborate; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; sodium t-butanolate; tricyclohexylphosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;
DOI:10.1021/ol049316s