230615-48-2

Basic information

• Product Name: 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-
• Synonyms: 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-;2,3,4,5-Tetrahydro-3-(phenylmethyl)-1,5-methano-1H-3-benzazepine;5-tetrahydro-3-(phenylMethyl)-;3-Benzyl-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine
• CAS NO: 230615-48-2
• Molecular Formula: C₁₈H₁₉N
• Molecular Weight: 249.35
• Mol File: 230615-48-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 374.495 °C at 760 mmHg
• Flash Point: 162.136 °C
• Appearance: /
• Density: 1.122
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-(230615-48-2)
• EPA Substance Registry System: 1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-(230615-48-2)

Safety Data

• Hazardous Substances Data: 230615-48-2(Hazardous Substances Data)

Usage

General Description

"1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-3-(phenylmethyl)-" is a complex organic compound that belongs to the benzazepines class of chemicals. Benzazepines are seven-membered heterocyclic compounds with two nitrogen atoms. Like many other organic compounds, it has potential uses in pharmaceuticals and medicine due to the pharmacological activity of benzazepines. However, details about its specific uses, functions, or properties are not readily available, suggesting that it might only exist as a theoretical molecule or in research settings. As this chemical is not widely studied, precautions must be taken when handling it due to the potential risks associated with unknown substances.

InChI:InChI=1/C18H19N/c1-2-6-14(7-3-1)11-19-12-15-10-16(13-19)18-9-5-4-8-17(15)18/h1-9,15-16H,10-13H2

Upstream product

• 26326-70-5 (1R,2R,3S,4S)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-2,3-diol 
• 542-92-7 cyclopenta-1,3-diene 
• 230615-47-1 1,2,3,4-tetrahydro-1,4-methano-naphthalene-cis-2,3-diol 
• 100-46-9 benzylamine 
• 75-34-3 1,1-dichloroethane 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 230615-52-8 2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride 
• 357425-93-5 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine p-toluenesulfonic acid salt 

Relevant articles and documents

Synthesis of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine via oxidative cleavage and reductive amination strategies

Preparations of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine (5) from benzonorbornadiene (1) by oxidative cleavage and reductive amination sequences were investigated. Osmium-mediated dihydroxylation of 1 followed by NaIO 4 cleavage, reductive amination and debenzylation provides 5 in 64-73% yield overall in three operations. A tandem ozonolysis-reductive amination procedure gives 5 as the tosylate salt from benzonorbornadiene with no isolation of intermediates in 28% yield.

Process for preparing varenicline and intermediates for use therein

The present invention relates to an improved process for preparing varenicline, or pharmaceutically acceptable salts or solvates thereof, and in particular an improved process for preparing varenicline, or pharmaceutically acceptable salts or solvates thereof, employing intermediate compounds 1,2,3,4-tetrahydro-1,4-methano-naphthalene-cis-2,3-diol (a compound of Formula III), and / or indane-1,3-dicarbaldehyde (a compound of Formula IV) as prepared by a process of the present invention.

Aryl fused azapolycyclic compounds

Compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; a