Technology Process of ST5741
There total 5 articles about ST5741 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-3-(3’-adamantan-1-yl-4’-cyanomethoxy-biphenyl-4-yl)acrylic acid methyl ester;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid; sulfuric acid / 96 h / 20 °C
2: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 4 h / 50 - 110 °C
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
4: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C
With
lithium hydroxide monohydrate; sulfuric acid; palladium diacetate; potassium carbonate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; potassium iodide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
2: |Heck Reaction;
DOI:10.1016/j.ejmech.2014.04.021
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
2: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Darkness
With
lithium hydroxide monohydrate; potassium carbonate; potassium iodide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.042
