N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

Base Information

Chemical Name:N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine
CAS No.:939039-15-3
Molecular Formula:C₂₂H₁₇ClF₄N₆
Molecular Weight:476.864
Hs Code.:

Synonyms:N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

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Chemical Property of N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

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Technology Process of N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

There total 4 articles about N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 939039-52-8
C₁₅H₉ClF₄N₆

: 6921-34-2
benzylmagnesium chloride

: 939039-15-3
N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

Guidance literature:: In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2013.12.088

Reference yield: 16.0%

: (E)-N-((5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methylene)-2-methyl-2H-tetrazol-5-amine

: 6921-34-2
benzylmagnesium chloride

: 939039-15-3
N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

Guidance literature:: (E)-N-((5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methylene)-2-methyl-2H-tetrazol-5-amine; benzylmagnesium chloride; In diethyl ether; dichloromethane; at -78 - 20 ℃; for 0.583333h;

With water; ammonium chloride; In diethyl ether; dichloromethane;

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 939039-15-3
N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-2-methyl-2H-tetrazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether

1.2: -78 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 16 h / 150 °C

3.1: dichloromethane / -78 - 20 °C

With n-butyllithium; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane; 1.2: |Strecker Aminoacid Synthesis / 3.1: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.bmcl.2013.12.088