(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

Base Information

Chemical Name:(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide
CAS No.:1582806-62-9
Molecular Formula:C₁₉H₁₁F₇N₂O₃
Molecular Weight:448.297
Hs Code.:

Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

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Technology Process of (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

There total 2 articles about (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1582806-46-9
(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 74-88-4
methyl iodide

: 1582806-62-9
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

: (S)-2-(1,3-dioxoisoindolin-2-yl)-3-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

Guidance literature:: With 9-methyl-acridine; palladium(II) trifluoroacetate; silver pivalate; In 1,2-dichloro-ethane; at 80 ℃; for 20h; Sealed tube;
DOI:10.1021/ja508165a

Reference yield:

: 1582806-62-9
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

Guidance literature:: In toluene; for 12h; Reflux;

Reference yield: 88.0%

: 624-31-7
4-tolyl iodide

: 1582806-62-9
(S)-2-(1,3-dioxoisoindolin-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

: 1582807-23-5
(2S,3S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-3-(p-tolyl)butanamide

: 1582807-02-0
(2S,3R)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-3-(p-tolyl)butanamide

Guidance literature:: With palladium(II) trifluoroacetate; 3,4-dihydro-2,5-dimethyl-2H-pyrano<2,3-b>quinoline; silver carbonate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 20h; Sealed tube;