1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Base Information

• Chemical Name: 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride
• CAS No.: 80907-82-0
• Molecular Formula: C₃₁H₂₉NO₃*ClH
• Molecular Weight: 500.037
• Mol file: 80907-82-0.mol

Synonyms:1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Chemical Property of 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride

There total 3 articles about 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(3-methoxyphenethyl)-2-<3,5-bis(benzyloxy)phenyl>acetamide (80907-81-9) → 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride (80907-82-0)

Guidance literature:

With trichlorophosphate; In acetonitrile; for 2h; Heating;

DOI:10.1021/jo00348a022

Reference yield:

3-methoxyphenylacetonitrile (19924-43-7) → 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride (80907-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / H₂ / Raney nickel / ethanol

2: 97 percent / xylene / 60 h / Heating

3: 91 percent / POCl₃ / acetonitrile / 2 h / Heating

With hydrogen; trichlorophosphate; nickel; In ethanol; acetonitrile; xylene;

DOI:10.1021/jo00348a022

Reference yield:

2-(3-methoxyphenyl)-1-ethanamine (2039-67-0) → 1-<3,5-bis(benzyloxy)benzyl>-6-methoxy-3,4-dihydroisoquinoline hydrochloride (80907-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / xylene / 60 h / Heating

2: 91 percent / POCl₃ / acetonitrile / 2 h / Heating

With trichlorophosphate; In acetonitrile; xylene;

DOI:10.1021/jo00348a022

upstream raw materials:

N-(3-methoxyphenethyl)-2-<3,5-bis(benzyloxy)phenyl>acetamide

3-methoxyphenylacetonitrile

2-(3-methoxyphenyl)-1-ethanamine

Downstream raw materials:

1-(3',5'-dihydroxybenzyl)-6-methoxy-1,2,3,4,5,8-hexahydroisoquinoline