N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide

Base Information

• Chemical Name: N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide
• CAS No.: 103477-30-1
• Molecular Formula: C₂₉H₄₅N₅O₅Si₂
• Molecular Weight: 599.878
• Mol file: 103477-30-1.mol

Synonyms:N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide

Chemical Property of N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide

There total 1 articles about N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C36H50N8O5Si2 → N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide (103477-30-1)

Guidance literature:

With diphenyl(methyl)phosphine; In 1,4-dioxane; water; at 20 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2008.05.053

Reference yield: 93.0%

N,N-diisopropylphosphoramide dichloride (921-26-6) + N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide (103477-30-1) → 3-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-diisopropylamino-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8-phospha-cyclopenta[b]naphthalen-9-one (103457-18-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 20 ℃; for 0.333333h;

DOI:10.1021/jo00368a037

Reference yield: 85.0%

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + N-{9-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-benzamide (103477-30-1) → C44H67N5O7SSi2

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2008.05.053

Downstream raw materials:

3-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-diisopropylamino-6-phenyl-3H-7-oxa-1,3,4,5,8a-pentaaza-8-phospha-cyclopenta[b]naphthalen-9-one