1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

Base Information

• Chemical Name: 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol
• CAS No.: 165689-84-9
• Molecular Formula: C₃₀H₄₆O₁₀Si
• Molecular Weight: 594.775
• Mol file: 165689-84-9.mol

Synonyms:1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

Chemical Property of 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

There total 7 articles about 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1D-1-O-(tert-butyldiphenylsilyl)-3-O-benzoyl-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol (496808-48-1) → 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol (165689-84-9)

Guidance literature:

With sodium methylate; In methanol; for 3h;

DOI:10.1021/jo0206418

Reference yield:

1D-1-O-tert-butyldiphenylsilyl-2,4,5,6-O-tetrakis(methoxymethylene)-3-O-triethylsilyl-myo-inositol (1228359-87-2) → 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol (165689-84-9)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo100393c

Reference yield:

2,3-O-(D-1,7,7-trimethylbicyclo[2.2.1]hept-6-ylidene)-D-myo-inositol (331679-26-6) → 1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol (165689-84-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / imidazole

2: 90 percent / HSCH₂CH₂OH; BF₃*Et₂O

3: 73 percent / pyridine / CHCl₃ / 6 h / -40 - 20 °C

4: 77 percent / trifluoroacetic acid / CHCl₃; H₂O / 24 h / 65 °C

5: 90 percent / sodium methoxide / methanol / 3 h

With pyridine; 1H-imidazole; boron trifluoride diethyl etherate; sodium methylate; trifluoroacetic acid; 2-hydroxyethanethiol; In methanol; chloroform; water;

DOI:10.1021/jo0206418

upstream raw materials:

1D-1-O-(tert-butyldiphenylsilyl)-3-O-benzoyl-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

2,3-O-(D-1,7,7-trimethylbicyclo[2.2.1]hept-6-ylidene)-D-myo-inositol

1D-1-O-(tert-butyldiphenylsilyl)-myo-inositol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(Z)-Octadec-9-enoic acid (R)-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-1-((Z)-octadec-9-enoyloxymethyl)-ethyl ester

Hexadecanoic acid (R)-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-1-hexadecanoyloxymethyl-ethyl ester

Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Fluoromethyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester