Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Base Information

Chemical Name:Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester
CAS No.:876310-63-3
Molecular Formula:C₃₂H₅₁O₁₂PSi
Molecular Weight:686.809
Hs Code.:

Synonyms:Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

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Chemical Property of Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

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Technology Process of Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

There total 1 articles about Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1066-52-0
methyl methylphosphonochloridate

: 165689-84-9
1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

: 876310-63-3
Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Guidance literature:: With potassium tert-butylate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja0554716

Reference yield:

: 876310-63-3
Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 876310-68-8
Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrakis-methoxymethoxy-5-(methoxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 18 h / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂; tetrahydrofuran / 20 h / 20 °C

2.2: 73 percent / n-Bu₄NIO₄ / CH₂Cl₂; tetrahydrofuran / 1.5 h / -20 - 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716

Reference yield:

: 876310-63-3
Methyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: Butyric acid (R)-1-butyryloxymethyl-2-{hydroxy-[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(hydroxy-methyl-phosphinoyloxy)-cyclohexyloxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 18 h / 20 °C

2.1: 1H-tetrazole / tetrahydrofuran / 16 h / 20 °C

2.2: 87 percent / n-Bu₄NIO₄ / tetrahydrofuran / 1.5 h / -20 - 20 °C

3.1: TMS-Br / CH₂Cl₂ / 0.5 h / 20 °C

3.2: H₂O / methanol / 0.5 h / 20 °C

3.3: 94 percent / ethanethiol / 1 h / 20 °C

With 1H-tetrazole; trimethylsilyl bromide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716