(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

Base Information

Chemical Name:(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide
CAS No.:1415635-78-7
Molecular Formula:C₂₅H₃₃NO₄
Molecular Weight:411.541
Hs Code.:

Synonyms:(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

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Chemical Property of (R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

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Technology Process of (R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

There total 1 articles about (R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 1-({[(2Z)-4-bromobut-2-en-1-yl]oxy}methyl)-4-methoxybenzene

: 1415635-78-7
(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.41667h; Inert atmosphere;

1-({[(2Z)-4-bromobut-2-en-1-yl]oxy}methyl)-4-methoxybenzene; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol302999v

Reference yield: 84.0%

: 1415635-78-7
(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

: 1385018-40-5
(R,Z)-6-((4-methoxybenzyl)oxy)-2-methylhex-4-enal

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; hexane; ethyl acetate; at -78 - 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol302999v

Reference yield:

: 1415635-78-7
(R,Z)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-6-((4-methoxybenzyl)oxy)-N,2-dimethylhex-4-enamide

: (2S,3R,4R,Z)-3-hydroxy-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-8-((4-methoxybenzyl)oxy)-N,2,4-trimethyloct-6-enamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; hexane; ethyl acetate / 1 h / -78 - 0 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.67 h / -78 - 20 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

2.3: 3 h / -116 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;
DOI:10.1021/ol302999v