(S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

Base Information

Chemical Name:(S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate
CAS No.:1071527-98-4
Molecular Formula:C₁₉H₂₆BrF₂NO₃Si
Molecular Weight:462.407
Hs Code.:

Synonyms:(S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

Suppliers and Price of (S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

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Technology Process of (S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

There total 2 articles about (S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 911395-59-0
(-)-2-(trimethylsilyl)ethyl (1S)-1-amino-2,2-difluorocyclohexane-1-carboxylate

: 586-75-4
4-chlorobenzoyl chloride

: 1071527-98-4
(S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.200702009

Reference yield:

: 1309655-30-8
C₂₁H₃₁F₂NO₃Si

: 1071527-98-4
(S)-2-(trimethylsilyl)ethyl 1-(4-bromobenzamido)-2,2-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OH)2 (10% on C); hydrogen / ethanol / 760.05 Torr / Inert atmosphere

2: dmap; triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; Pd(OH)2 (10% on C); hydrogen; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1002/chem.201100113