methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

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Chemical Name:methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate
CAS No.:1301620-72-3
Molecular Formula:C₂₇H₃₈N₄O₆
Molecular Weight:514.622
Hs Code.:

Synonyms:methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

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Chemical Property of methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

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Technology Process of methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

There total 4 articles about methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₂N₄O₄

: 105-36-2
ethyl bromoacetate

: 1301620-72-3
methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.071

Reference yield:

: 1169762-18-8
(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidine

: 1301620-72-3
methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1 h / 50 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.02.071

Reference yield:

: C₁₇H₂₇N₃O₄S

: 1301620-72-3
methyl 3-[benzyl(2-ethoxy-2-oxoethyl)amino]-3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyanoprop-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2011.02.071