Technology Process of (2S,3R,6S)-3-benzyloxy-N-benzyloxycarbonyl-6-dodecyl-2-vinylpiperidine
There total 12 articles about (2S,3R,6S)-3-benzyloxy-N-benzyloxycarbonyl-6-dodecyl-2-vinylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: NaBH4 / ethanol / -78 °C
2: 98 percent / NaH, N(Bu4)I / tetrahydrofuran / Ambient temperature
3: 78 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O / Ambient temperature
4: diethyl ether / Ambient temperature
5: PDC / CH2Cl2 / Ambient temperature
6: 1.) CF3COOH / 1.) ClCH2CH2Cl, rt.; 2.) water
7: 1.) AgBF4; 2.) Zn(BH4)2 / 1.) THF, -78 deg C
8: 86 percent / tetrahydrofuran / Ambient temperature
9: thionyl chloride / tetrahydrofuran / Ambient temperature
10: KCN / dimethylsulfoxide; tetrahydrofuran
11: 83 percent / DMAP / CH2Cl2 / Ambient temperature
With
dmap; potassium cyanide; sodium tetrahydroborate; sodium periodate; dipyridinium dichromate; silver tetrafluoroborate; thionyl chloride; zinc(II) tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid;
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00646-7
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 78 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O / Ambient temperature
2: diethyl ether / Ambient temperature
3: PDC / CH2Cl2 / Ambient temperature
4: 1.) CF3COOH / 1.) ClCH2CH2Cl, rt.; 2.) water
5: 1.) AgBF4; 2.) Zn(BH4)2 / 1.) THF, -78 deg C
6: 86 percent / tetrahydrofuran / Ambient temperature
7: thionyl chloride / tetrahydrofuran / Ambient temperature
8: KCN / dimethylsulfoxide; tetrahydrofuran
9: 83 percent / DMAP / CH2Cl2 / Ambient temperature
With
dmap; potassium cyanide; sodium periodate; dipyridinium dichromate; silver tetrafluoroborate; thionyl chloride; zinc(II) tetrahydroborate; trifluoroacetic acid;
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00646-7
