Technology Process of (3R,5S,8R,8aR)-8-Benzyloxy-5-dodecyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine
There total 10 articles about (3R,5S,8R,8aR)-8-Benzyloxy-5-dodecyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrahydrofuran / Ambient temperature
2: NaBH4 / ethanol / -78 °C
3: 98 percent / NaH, N(Bu4)I / tetrahydrofuran / Ambient temperature
4: 78 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O / Ambient temperature
5: diethyl ether / Ambient temperature
6: PDC / CH2Cl2 / Ambient temperature
7: 1.) CF3COOH / 1.) ClCH2CH2Cl, rt.; 2.) water
8: 1.) AgBF4; 2.) Zn(BH4)2 / 1.) THF, -78 deg C
With
sodium tetrahydroborate; sodium periodate; dipyridinium dichromate; silver tetrafluoroborate; zinc(II) tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid;
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00646-7
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaBH4 / ethanol / -78 °C
2: 98 percent / NaH, N(Bu4)I / tetrahydrofuran / Ambient temperature
3: 78 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O / Ambient temperature
4: diethyl ether / Ambient temperature
5: PDC / CH2Cl2 / Ambient temperature
6: 1.) CF3COOH / 1.) ClCH2CH2Cl, rt.; 2.) water
7: 1.) AgBF4; 2.) Zn(BH4)2 / 1.) THF, -78 deg C
With
sodium tetrahydroborate; sodium periodate; dipyridinium dichromate; silver tetrafluoroborate; zinc(II) tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid;
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00646-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / NaH, N(Bu4)I / tetrahydrofuran / Ambient temperature
2: 78 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O / Ambient temperature
3: diethyl ether / Ambient temperature
4: PDC / CH2Cl2 / Ambient temperature
5: 1.) CF3COOH / 1.) ClCH2CH2Cl, rt.; 2.) water
6: 1.) AgBF4; 2.) Zn(BH4)2 / 1.) THF, -78 deg C
With
sodium periodate; dipyridinium dichromate; silver tetrafluoroborate; zinc(II) tetrahydroborate; tetra-(n-butyl)ammonium iodide; sodium hydride; trifluoroacetic acid;
osmium(VIII) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00646-7
