(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Base Information

Chemical Name:(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal
CAS No.:1551543-94-2
Molecular Formula:C₂₇H₄₆O₅Si
Molecular Weight:478.745
Hs Code.:

Synonyms:(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Suppliers and Price of (4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

There total 5 articles about (4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1551543-91-9
(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-en-1-ol

: 1551543-94-2
(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃;
DOI:10.1021/ol500004k

Reference yield:

: 1551543-71-5
(4R,5S,6S,7R,E)-methyl 5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enoate

: 1551543-94-2
(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 0 °C

With lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol500004k

Reference yield:

: 1551543-85-1
(2S,4R,5R)-1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,4-dimethylheptane-1,3-dione

: 1551543-94-2
(4R,5S,6R,7R,E)-5-((tert-butyldimethylsilyl)oxy)-7-methoxy-9-((4-methoxybenzyl)oxy)-2,4,6-trimethylnon-2-enal

Guidance literature:: Multi-step reaction with 6 steps

1: lithium borohydride / diethyl ether / 0.33 h / -26 - -15 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 7 h / 20 °C

3: dichloromethane / 18 h / 20 °C

4: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

6: Dess-Martin periodane / dichloromethane / 0 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium borohydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; 3: |Wittig Olefination;
DOI:10.1021/ol500004k