Technology Process of (R,R)-tapentadol-PABA carbamate trifluoroacetate
There total 9 articles about (R,R)-tapentadol-PABA carbamate trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetone; methanol
2.1: diethylamine / tert-butyl methyl ether
3.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C
3.2: 5 °C
4.1: hydrogenchloride / water / 5 h / 55 °C
4.2: 20 °C / pH 12
5.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere
6.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C
6.2: pH 10 - 12
7.1: toluene / Reflux
8.1: 1 h / 20 °C
With
hydrogenchloride; methanesulfonic acid; hydrogen; diethylamine; DL-methionine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; tert-butyl methyl ether; water; acetone; toluene;
3.1: Grignard Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere
2.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C
2.2: pH 10 - 12
3.1: toluene / Reflux
4.1: 1 h / 20 °C
With
hydrogenchloride; methanesulfonic acid; hydrogen; DL-methionine;
palladium 10% on activated carbon;
In
ethanol; water; toluene;
