2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

Base Information

Chemical Name:2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide
CAS No.:1534370-70-1
Molecular Formula:C₁₇H₁₂BrF₃N₂O₃
Molecular Weight:429.193
Hs Code.:

Synonyms:2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

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Chemical Property of 2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

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Technology Process of 2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

There total 5 articles about 2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid

: 41419-59-4
N-methyl-4-(trifluoromethoxy)aniline

: 1534370-70-1
2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1055/s-0033-1339799

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1534370-70-1
2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice; Inert atmosphere

3: hydrogenchloride; acetic acid / 1,4-dioxane / 6.5 h / 50 °C / Inert atmosphere

4: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339799

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 1534370-70-1
2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-[4-(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 5% rhodium-on-charcoal; hydrogen / tetrahydrofuran / 11 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice; Inert atmosphere

4: hydrogenchloride; acetic acid / 1,4-dioxane / 6.5 h / 50 °C / Inert atmosphere

5: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; 5% rhodium-on-charcoal; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339799