N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine
• CAS No.: 1051897-37-0
• Molecular Formula: C₂₇H₃₅N₇O₂
• Molecular Weight: 489.621

Synonyms:N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine

Chemical Property of N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine

There total 5 articles about N₄-(5-methoxy-2-methylphenyl)-N₄-methyl-N₂-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

tert-butyl 4-(3-(4-((5-methoxy-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)piperazine-1-carboxylate (1051899-50-3) → N4-(5-methoxy-2-methylphenyl)-N4-methyl-N2-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine (1051897-37-0)

Guidance literature:

With hydrogenchloride; In dichloromethane; isopropyl alcohol; at 25 ℃; for 2h;

Reference yield:

tert-butyl 4-(3-morpholino-5-nitrophenyl)piperazine-1-carboxylate (1051899-47-8) → N4-(5-methoxy-2-methylphenyl)-N4-methyl-N2-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine (1051897-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / platinum(IV) oxide / ethanol / 2.5 h / 825.08 Torr

2: pentanol, 2- / 1.5 h / 120 °C

3: hydrogenchloride / dichloromethane; isopropyl alcohol / 2 h / 25 °C

With hydrogenchloride; hydrogen; platinum(IV) oxide; In pentanol, 2-; ethanol; dichloromethane; isopropyl alcohol;

Reference yield:

1-fluoro-3-iodo-5-nitrobenzene (3819-88-3) → N4-(5-methoxy-2-methylphenyl)-N4-methyl-N2-(3-morpholino-5-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine (1051897-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 4 h / 90 °C

2: caesium carbonate; 2,2'-bis(diphenylphosphino)biphenyl / palladium diacetate / toluene / 2 h / Heating / reflux

3: hydrogen / platinum(IV) oxide / ethanol / 2.5 h / 825.08 Torr

4: pentanol, 2- / 1.5 h / 120 °C

5: hydrogenchloride / dichloromethane; isopropyl alcohol / 2 h / 25 °C

With hydrogenchloride; hydrogen; caesium carbonate; 2,2'-bis(diphenylphosphino)biphenyl; platinum(IV) oxide; palladium diacetate; In pentanol, 2-; ethanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; toluene;

upstream raw materials:

tert-butyl 4-(3-(4-((5-methoxy-2-methylphenyl)(methyl)amino)pyrimidin-2-ylamino)-5-morpholinophenyl)piperazine-1-carboxylate

4-(3-iodo-5-nitrophenyl)-morpholine

3-(4-tert-butoxycarbonylpiperazino)-5-morpholinoaniline

tert-butyl 4-(3-morpholino-5-nitrophenyl)piperazine-1-carboxylate

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