3819-88-3

Basic information

• Product Name: 1-FLUORO-3-IODO-5-NITROBENZENE
• Synonyms: BENZENE, 1-FLUORO-3-IODO-5-NITRO-;1-FLUORO-3-IODO-5-NITROBENZENE;3-NITRO-5-FLUORO-IODO-BENZENE;3-FLUORO-5-IODONITROBENZENE;1-Fluoro-3-iodo-5-nitrobenzene,98%;3-Fluoro-5-iodonitrobenzen
• CAS NO: 3819-88-3
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 267
• Product Categories: Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 3819-88-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 77-79 °C(lit.)
• Boiling Point: 277.7±20.0 °C at 760 mmHg
• Flash Point: 121.7±21.8 °C
• Appearance: Yellow to khaki or brown/Powder and/or Chunks
• Density: 2.1±0.1 g/cm³
• Vapor Pressure: 0.00753mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• Sensitive: Light Sensitive
• CAS DataBase Reference: 1-FLUORO-3-IODO-5-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUORO-3-IODO-5-NITROBENZENE(3819-88-3)
• EPA Substance Registry System: 1-FLUORO-3-IODO-5-NITROBENZENE(3819-88-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 3819-88-3(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder and chunks

Uses

1-Fluoro-3-iodo-5-nitrobenzene may be used in chemical synthesis.

InChI:InChI=1/C6H3FINO2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H

Upstream product

• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 10394-64-6 3-nitro-5-iodoaniline 
• 99-65-0 meta-dinitrobenzene 

Downstream Products

• 1051899-19-4 4-(3-iodo-5-nitrophenyl)-morpholine 
• 7087-27-6 1-fluoro-3-(methylsulfonyl)-5-nitrobenzene 
• 1421681-14-2 C₁₀H₈FN₃O₂ 
• 1421681-16-4 C₁₀H₁₀FN₃ 
• 1421681-18-6 C₂₇H₂₂FN₇O 
• 110882-60-5 3-fluoro-5-nitrobenzonitrile 
• 1312572-93-2 N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine 
• 1312572-92-1 5-[3-amino-5-(morpholin-4-yl)phenyl]-N,N-bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-1,3-thiazol-2-amine 
• 1312572-91-0 N,N-bis(2-{[tert-butyl-(diphenyl)silyl]oxy}ethyl)-5-[3-(morpholin-4-yl)-5-nitrophenyl]-1,3-thiazol-2-amine 
• 1312572-26-1 2,2'-({5-[3-(morpholin-4-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}imino)diethanol 
• 1129540-90-4 4-[3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine 
• 1338367-32-0 [(3-fluoro-5-nitrophenyl)ethynyl](trimethyl)silane 
• 1211529-88-2 (3-fluoro-5-nitrophenyl)acetic acid 
• 1338367-31-9 methyl (3-amino-5-fluorophenyl)acetate 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Steroid receptor modulator compounds and methods

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.