4-Glycidyloxy-2-indolecarbonitrile

Base Information

Chemical Name:4-Glycidyloxy-2-indolecarbonitrile
CAS No.:73907-82-1
Molecular Formula:C12H10 N2 O2
Molecular Weight:214.22
Hs Code.:
DSSTox Substance ID:DTXSID50472859
Mol file:73907-82-1.mol

Synonyms:4-glycidyloxy-2-indolecarbonitrile;73907-82-1;4-(oxiran-2-ylmethoxy)-1H-indole-2-carbonitrile;4-(2-oxiranylmethoxy)-1H-indole-2-carbonitrile;SCHEMBL4386345;DTXSID50472859;WANDYUHWUAJSBK-UHFFFAOYSA-N;2-cyano-4-(2,3-epoxy-propoxy)-indol;4-(2,3-epoxypropoxy)-1H-indole-2-carbonitrile

Suppliers and Price of 4-Glycidyloxy-2-indolecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 4-Glycidyloxy-2-indolecarbonitrile

Chemical Property:

PSA：61.34000
LogP:1.81718
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:214.074227566
Heavy Atom Count:16
Complexity:311

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(O1)COC2=CC=CC3=C2C=C(N3)C#N

Technology Process of 4-Glycidyloxy-2-indolecarbonitrile

There total 7 articles about 4-Glycidyloxy-2-indolecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 106469-57-2
4-hydroxy-1H-indole-2-carbonitrile

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 73907-82-1
4-(2,3-epoxypropoxy)-1H-indol-2-carbonitrile

Guidance literature:: With morpholine; for 2.5h; Heating;
DOI:10.1021/jm00387a005

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 35308-87-3
4-(oxiranylmethoxy)-1H-indole

: 39731-09-4
4-benzyloxylindole-2-carboxylic acid

: 73907-82-1
4-(2,3-epoxypropoxy)-1H-indol-2-carbonitrile

Guidance literature:: 1-methyl-piperazine; In epichlorohydrin;

Reference yield:

: 39731-09-4
4-benzyloxylindole-2-carboxylic acid

: 73907-82-1
4-(2,3-epoxypropoxy)-1H-indol-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂, DMF / CH₂Cl₂ / 3 h / Ambient temperature

2: NH₃ / CH₂Cl₂; diethyl ether / -20 °C

3: 83 percent / trifluoroacetic acid anhydride, pyridine / 2 h / 0 °C

4: 82 percent / ammonium formate / 5percent Pd/C / methanol / a) RT, 1 h, b) reflux

5: 75 percent / morpholine / 2.5 h / Heating

With morpholine; pyridine; thionyl chloride; ammonia; ammonium formate; N,N-dimethyl-formamide; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00387a005