39731-09-4

Basic information

• Product Name: 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID
• Synonyms: AKOS JY2083405;4-(BENZYLOXY)-1H-INDOLE-2-CARBOXYLIC ACID;4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID
• CAS NO: 39731-09-4
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.28
• Product Categories: Indoles and derivatives
• Mol File: 39731-09-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID(39731-09-4)
• EPA Substance Registry System: 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID(39731-09-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 39731-09-4(Hazardous Substances Data)

Usage

General Description

4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID, also known as 4-benzyloxy-1H-indole-2-carboxylic acid, is a chemical compound with the molecular formula C16H13NO3. It is a derivative of indole carboxylic acid, which is commonly used in the synthesis of various pharmaceuticals and organic compounds. 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID has been studied for its potential biological activities, including its role as an inhibitor of enzymes and its potential use as a building block for the synthesis of other complex organic molecules. It is a white to off-white powder with a melting point of approximately 230°C and is typically handled and stored under standard laboratory conditions. Overall, 4-BENZYLOXYINDOLE-2-CARBOXYLIC ACID is a versatile chemical that has potential applications in pharmaceutical and chemical research and development.

Upstream product

• 27737-55-9 4-benzyloxy-1H-indole-2-carboxylic acid ethyl ester 
• 2380-94-1 1H-indol-4-ol 
• 35308-87-3 4-(oxiranylmethoxy)-1H-indole 
• 7647-01-0 hydrogenchloride 
• 95264-30-5 (Z)-ethyl 2-azido-3-(2-(benzyloxy)phenyl)acrylate 
• 20876-37-3 2-benzyloxy-6-nitrotoluene 
• 95-92-1 oxalic acid diethyl ester 
• 100-44-7 benzyl chloride 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 

Downstream Products

• 13523-95-0 4-benzyloxy-3-dimethylaminomethylindole 
• 110336-81-7 (4-benzyloxy-indol-2-yl)-acetic acid dimethylamide 
• 94308-65-3 [2-(4-benzyloxy-indol-2-yl)-ethyl]-dimethyl-amine 
• 75303-01-4 (4-benzyloxy-indol-2-ylmethyl)-dimethyl-amine 
• 1464-11-5 4-benzyloxyindole-3-acetonitrile 
• 109249-04-9 2-(4-(benzyloxy)-1H-indol-3-yl)ethanamine 
• 108981-51-7 (4-benzyloxy-indol-2-yl)-acetonitrile 
• 2380-94-1 1H-indol-4-ol 
• 73907-82-1 4-(2,3-epoxypropoxy)-1H-indol-2-carbonitrile 
• 126953-42-2 4-(3-{4-[1-(2,4-Dinitro-phenylamino)-1-methyl-ethyl]-1-methyl-cyclohexylamino}-2-hydroxy-propoxy)-1H-indole-2-carbonitrile 
• 106502-44-7 4-{3-[4-(1-Amino-1-methyl-ethyl)-1-methyl-cyclohexylamino]-2-hydroxy-propoxy}-1H-indole-2-carbonitrile 
• 106469-50-5 4-{3-[1-(4-Amino-4-methyl-cyclohexyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-1H-indole-2-carbonitrile 
• 106469-56-1 2-cyano-4-(benzyloxy)indole 
• 106469-57-2 4-hydroxy-1H-indole-2-carbonitrile 

Relevant articles and documents

Phenoxypropylamine compounds

The present invention relates to a phenoxypropylamine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt thereof and hydrates thereof, which simultaneously show selective affinity for and antagonistic activity against 5-HT1A receptor, as well as 5-HT reuptake inhibitory activity, and can be used as antidepressants quick in expressing an anti-depressive effect.

INDOLOYLGUANIDINE DERIVATIVES

-

Novel Indole-2-carboxylates as Ligands for the Strychnine-Insensitive N-Methyl-D-aspartate-Linked Glycine Receptor

A series of indole-2-carboxylates were prepared and evaluated for their ability to inhibit the binding at the strychnine-insensitive glycine receptor that is associated with the NMDA-PCP-glycine receptor complex.All of the compounds were selective for the glycine site relative to other sites on the receptor macrocomplex and several of the compounds in this series were found to have submicromolar affinity for this receptor.The lead compound, 2-carboxy-6-chloro-3-indoleacetic acid (Ki = 1.6 μM vsglycine), was also found to noncompetitively inhibit the binding of MK-801, a ligand for the phencyclidine site on the receptor macrocomplex.These latter data suggest that the compound functions as an antagonist at the strychnine-insensitive glycine receptor.The structural activity relationships within this series of indole-2-carboxylates is discussed and several key pharmacophores are identified for this series of glycine ligands.In general, the most potent compounds were the C-3 acetamides, with N-propyl-2-carboxy-6-chloro-3-indoleacetamide having the highest receptor affinity.