(S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate
CAS No.:1187056-45-6
Molecular Formula:C₂₅H₂₈FN₅O₃S
Molecular Weight:497.593
Hs Code.:

Synonyms:(S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

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Chemical Property of (S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

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Technology Process of (S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

There total 2 articles about (S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

: 1187056-44-5
(S)-tert-butyl 1-(3-(2-bromothiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

: 1993-03-9
o-fluorophenylboronic acid

: 1187056-45-6
(S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

Guidance literature:: With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; acetonitrile; at 110 ℃; for 0.25h; Sealed tube; Microwave irradiation;

Reference yield:

: 1023298-99-8
(S)-1-(3-aminopyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester

: 1187056-45-6
(S)-tert-butyl 1-(3-(2-(2-fluorophenyl)thiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

2: sodium carbonate; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 0.25 h / 110 °C / Sealed tube; Microwave irradiation

With potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; acetonitrile;