(S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate
• CAS No.: 1023298-99-8
• Molecular Formula: C15H24N4O2
• Molecular Weight: 292.381
• Hs Code.: 2933990090
• Mol file: 1023298-99-8.mol

Synonyms:(S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate;tert-butyl ((3S)-1-(3-amino-4-pyridinyl)-3-piperidinyl)carbamate;

Chemical Property of (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate

Chemical Property:

• PSA: 80.48000
• LogP: 3.19440
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl(1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate

There total 4 articles about (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-1-(3-nitropyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester (1026669-77-1) → (S)-1-(3-aminopyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester (1023298-99-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 4h;

Reference yield: 78.0%

→ (S)-1-(3-aminopyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester (1023298-99-8)

Guidance literature:

Reference yield:

4-chloro-3-nitropyridine (13091-23-1) → (S)-1-(3-aminopyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester (1023298-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(isopropyl)ethylamine / ethanol / 48 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 15 h

With bis(isopropyl)ethylamine; palladium 10% on activated carbon; hydrogen; In ethanol;

DOI:10.1021/ml400307j

upstream raw materials:

(S)-1-(3-nitropyridin-4-yl)piperidin-3-yl-carbamic acid tert-butyl ester

4-chloro-3-nitropyridine

tert-butyl (S)-piperidin-3-yl-carbamate

Downstream raw materials:

N-(4-((3S)-3-amino-1-piperidinyl)-3-pyridinyl)-2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-amine

(S)-N-(4-(3-aminopiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide