4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester
CAS No.:167831-77-8
Molecular Formula:C₄₀H₃₆F₃NO₈S
Molecular Weight:747.789
Hs Code.:

Synonyms:4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

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Chemical Property of 4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

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Technology Process of 4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

There total 4 articles about 4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 167831-76-7
4-(2-amino-6-benzyloxybenzoyl)-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

: 167831-77-8
4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 10 ℃; for 5.5h;
DOI:10.1021/jm020018f

Reference yield:

: 158980-62-2
3-Benzyloxy-2-[2,6-dibenzyloxy-4-(1,1-dimethylethoxycarbonyl)-benzoyl]benzoic acid

: 167831-77-8
4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diphenylphosphoryl azide; Et₃N / toluene / 3.5 h / 95 °C

2: toluene / 18 h / 95 °C

3: 87 percent / CsF / dimethylformamide / 48 h / 75 °C

4: 32 percent / 2,6-lutidine / CH₂Cl₂ / 5.5 h / 0 - 10 °C

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; triethylamine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide; toluene; 1: Curtis rearrangement;
DOI:10.1021/jm020018f

Reference yield:

: 3,5-bis-benzyloxy-4-(2-benzyloxy-6-isocyanato-benzoyl)-benzoic acid tert-butyl ester

: 167831-77-8
4-[2-benzyloxy-6-(trifluoromethylsulfonylamino)benzoyl]-3,5-dibenzyloxybenzoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 18 h / 95 °C

2: 87 percent / CsF / dimethylformamide / 48 h / 75 °C

3: 32 percent / 2,6-lutidine / CH₂Cl₂ / 5.5 h / 0 - 10 °C

With 2,6-dimethylpyridine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020018f