(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

Base Information

Chemical Name:(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one
CAS No.:214683-63-3
Molecular Formula:C₄₈H₆₁NO₃Si
Molecular Weight:728.103
Hs Code.:

Synonyms:(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

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Chemical Property of (S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

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Technology Process of (S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

There total 10 articles about (S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17156-64-8
(dimethylphenylsilyl)acetylene

: 214683-63-3
(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) MeMgCl / 1.) THF, r.t., 2 h, 2.) THF, -23 deg C, 30 min; r.t., 2 h

2: 64 percent / H₂, quinoline / 10percent Pd/BaSO₄ / methanol / 3 h

3: (COCl)2, DMF / CH₂Cl₂ / 1 h / Ambient temperature

4: n-BuLi / tetrahydrofuran; hexane / 1.) -20 deg C, 20 min, 2.) r.t., 30 min

With quinoline; n-butyllithium; oxalyl dichloride; hydrogen; methylmagnesium chloride; N,N-dimethyl-formamide; Pd-BaSO₄; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/a804275f

Reference yield:

: 130625-73-9
(Dimethyl-phenyl-silanyl)-propynoic acid

: 214683-63-3
(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / H₂, quinoline / 10percent Pd/BaSO₄ / methanol / 3 h

2: (COCl)2, DMF / CH₂Cl₂ / 1 h / Ambient temperature

3: n-BuLi / tetrahydrofuran; hexane / 1.) -20 deg C, 20 min, 2.) r.t., 30 min

With quinoline; n-butyllithium; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; Pd-BaSO₄; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1039/a804275f

Reference yield:

: 26186-02-7
tridec-1-yne

: 214683-63-3
(S)-1-[(E)-(R)-3-(Dimethyl-phenyl-silanyl)-hexadec-4-enoyl]-5-trityloxymethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / BuLi / tetrahydrofuran / 18 h / Heating

2: 1.) dicyclohexylborane, 2.) AcOH / 1.) THF, r.t., 2 h, 2.) THF, r.t., 1 h

3: Br₂ / CH₂Cl₂ / 0.17 h / -78 °C

4: NaOMe / methanol / 1.) 0 deg C, 1 h, 2.) r.t., 2 h

With n-butyllithium; bis(cyclohexanyl)borane; bromine; sodium methylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/a804275f