(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Base Information

Chemical Name:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
CAS No.:145250-92-6
Molecular Formula:C₂₆H₄₁N₃O₆
Molecular Weight:491.628
Hs Code.:

Synonyms:(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Chemical Property of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Technology Process of (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

There total 8 articles about (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 15136-32-0,87976-66-7,120342-25-8,5874-73-7
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

: 145250-92-6
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With sodium hydrogencarbonate; sodium carbonate; α-chymotrypsin; In Trichloroethylene; water; Petroleum ether; for 2h; Ambient temperature; pH=10;
DOI:10.1016/S0040-4039(00)77731-8

Reference yield: 82.0%

: Boc-Leu-Phe-Leu-OMe

: 145250-92-6
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Boc-Leu-Phe-Leu-OMe; With dihydrogen peroxide; lithium hydroxide; In methanol; at 0 ℃;

With hydrogenchloride; sodium thiosulfate; In methanol; water; pH=1;
DOI:10.1016/j.tet.2011.11.089

Reference yield: 78.0%

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 26055-05-0
N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine

: 145250-92-6
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With mercaptoethyl alcohol; McIlvaine buffer; papain; In tetrachloromethane; water; at 30 ℃; for 20h; pH=5.5;
DOI:10.1016/S0040-4039(00)77731-8