1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate
• CAS No.: 852999-37-2
• Molecular Formula: C₁₈H₁₉F₃O₄S
• Molecular Weight: 388.408
• Mol file: 852999-37-2.mol

Synonyms:1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate

Chemical Property of 1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate

There total 1 articles about 1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(2-methoxyphenyl)spiro[4.5]dec-1-en-6-one + N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) → 1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate (852999-37-2)

Guidance literature:

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.02.021

Reference yield: 61.0%

1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate (852999-37-2) + 2-Methoxyphenylboronic acid (5720-06-9) → 1,6-bis(methoxyphenyl)spiro[4.5]deca-1,6-diene

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 3h;

DOI:10.1016/j.tet.2005.02.021

Reference yield:

1-(2-methoxyphenyl)spiro[4.5]deca-1,6-dien-6-yl trifluoromethanesulfonate (852999-37-2) → cis,cis-1,6-bis(2-methoxyphenyl)spiro[4.5]decane

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane / 3 h / 100 °C

2: 73 percent / hydrogen / Pd/C / ethanol / 9 h / 20 °C / 760 Torr

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; 1: Suzuki coupling;

DOI:10.1016/j.tet.2005.02.021

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide