S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

Base Information

Chemical Name:S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate
CAS No.:1312707-38-2
Molecular Formula:C₂₉H₃₅NO₂S
Molecular Weight:461.668
Hs Code.:

Synonyms:S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

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Chemical Property of S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

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Technology Process of S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

There total 3 articles about S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 69746-43-6
1-iodo-4-thioacetylbenzene

: 1312707-38-2
S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c1cc11517k

Reference yield:

: 52928-01-5
4-iodothiophenol

: 1312707-38-2
S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1039/c1cc11517k

Reference yield:

: 98-61-3
p-Iodobenzenesulfonyl chloride

: 1312707-38-2
S-(4-((4-((-7-(hydroxymethyl)-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)methyl)phenyl)ethynyl)phenyl) thioacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl acetamide; dimethylsilicon dichloride; zinc / 1,2-dichloro-ethane / 1.5 h / Reflux; Inert atmosphere

2: 1,2-dichloro-ethane / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-dimethyl acetamide; dimethylsilicon dichloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1039/c1cc11517k