(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

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Chemical Name:(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one
CAS No.:198758-12-2
Molecular Formula:C₄₁H₇₅NO₉Si₂
Molecular Weight:782.219
Hs Code.:

(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

Synonyms:(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

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Chemical Property of (R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

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Technology Process of (R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

There total 18 articles about (R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 198758-11-1
(R)-N-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-4-hydroxy-3-methoxy-butyramide

: 198758-12-2
(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

Guidance literature:: With sulfur trioxide pyridine complex; In dimethyl sulfoxide;
DOI:10.1021/jo971793j

Reference yield:

: 74422-90-5
2,5-dimethoxy-3-nitrobenzaldehyde

: 198758-12-2
(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / BH₃*THF

2.1: 80 percent / CBr₄; PPh₃

3.1: 85 percent

4.1: 100 percent / H₂ / Pd/C

5.1: 70 percent / Me₃Al / benzene

6.1: 98 percent / imidazole

7.1: LHMDS / tetrahydrofuran / -78 °C

7.2: 80 percent / tetrahydrofuran

8.1: 98 percent / Na(Hg); Na₂HPO₄

9.1: 95 percent / HF*Pyr / pyridine

10.1: 80 percent / Pyr*SO₃ / dimethylsulfoxide

With 1H-imidazole; disodium hydrogenphosphate; sodium amalgam; borane-THF; carbon tetrabromide; hydrogen; trimethylaluminum; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; dimethyl sulfoxide; benzene; 1.1: Reduction / 2.1: Bromination / 3.1: Substitution / 4.1: Catalytic hydrogenation / 5.1: Weinreb-type amidation / 6.1: silylation / 7.1: Metallation / 7.2: Alkylation / 8.1: Reduction / 9.1: desilylation / 10.1: Parikh-Doering oxidation;
DOI:10.1021/jo971793j

Reference yield:

: 198758-08-6
2,5-dimethoxy-3-nitro-1-[(phenylsulfonyl)methyl]benzene

: 198758-12-2
(R)-1-{3-[(Z)-(5R,6S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-9,9-dimethoxy-4,6-dimethyl-7-triisopropylsilanyloxy-non-3-enyl]-2,5-dimethoxy-phenyl}-5-hydroxy-4-methoxy-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / H₂ / Pd/C

2.1: 70 percent / Me₃Al / benzene

3.1: 98 percent / imidazole

4.1: LHMDS / tetrahydrofuran / -78 °C

4.2: 80 percent / tetrahydrofuran

5.1: 98 percent / Na(Hg); Na₂HPO₄

6.1: 95 percent / HF*Pyr / pyridine

7.1: 80 percent / Pyr*SO₃ / dimethylsulfoxide

With 1H-imidazole; disodium hydrogenphosphate; sodium amalgam; hydrogen; trimethylaluminum; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; dimethyl sulfoxide; benzene; 1.1: Catalytic hydrogenation / 2.1: Weinreb-type amidation / 3.1: silylation / 4.1: Metallation / 4.2: Alkylation / 5.1: Reduction / 6.1: desilylation / 7.1: Parikh-Doering oxidation;
DOI:10.1021/jo971793j