4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Name:4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:173951-86-5
Molecular Formula:C₂₈H₃₃N₅O₅S
Molecular Weight:551.667
Hs Code.:

Synonyms:4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 173951-85-4
4-((4-(prop-2-ynylamino)phenyl)sulfonyl)-1-(tert-butyloxycarbonyl)piperazine

: 173951-86-5
4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1021/jm9502652

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 173951-86-5
4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 22 h / 2275.5 Torr

3: 55 percent / N,N-diisopropylethylamine / dimethylformamide; toluene / 8 h / 75 °C

4: 33 percent / 2,6-lutidine / dimethylformamide / 4 h / 100 °C

With 2,6-dimethylpyridine; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9502652

Reference yield:

: 173951-83-2
N-((4-nitrophenyl)sulfonyl)-1-(tert-butyloxycarbonyl)piperazine

: 173951-86-5
4-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzenesulfonyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 5percent Pd/C / ethyl acetate / 22 h / 2275.5 Torr

2: 55 percent / N,N-diisopropylethylamine / dimethylformamide; toluene / 8 h / 75 °C

3: 33 percent / 2,6-lutidine / dimethylformamide / 4 h / 100 °C

With 2,6-dimethylpyridine; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9502652