(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

Base Information

Chemical Name:(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one
CAS No.:110143-56-1
Molecular Formula:C₂₃H₂₈N₂O₃S
Molecular Weight:412.553
Hs Code.:

Synonyms:(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

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Chemical Property of (2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

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Technology Process of (2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

There total 10 articles about (2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 88767-98-0,138333-09-2
ethyl (R)-4-phenyl-2-<<(trifluoromethyl)sulfonyl>oxy>butyrate

: 110143-55-0
(2R,6R)-6-amino-2-phenylperhydro-1,4-thiazepin-5-one

: 110143-56-1
(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

Guidance literature:: With triethylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00394a009

Reference yield:

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 110143-56-1
(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 97 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; triethylamine; In dichloromethane;
DOI:10.1021/jm00394a009

Reference yield:

: 5153-67-3
nitrostyrene

: 110143-56-1
(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / toluene / 16 h / Ambient temperature

2: 51 percent / H₂, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr

3: 78 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature

4: 4 N aq. HCl / dioxane / 4 h / Ambient temperature

5: 97 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00394a009