(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

Base Information

Chemical Name:(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester
CAS No.:110510-47-9
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

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Chemical Property of (R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of (R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

There total 1 articles about (R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-96-4
ethyl bromide

: 102209-06-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3R,4S)-3-phenoxy-4-phenylazetidin-2-one

: 110510-47-9
(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 15 min, 2.) THF, -78 deg C, 5 h;
DOI:10.1021/ja00255a063

Reference yield:

: 110510-47-9
(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

: 3059-97-0,465-58-7
(2R)-2-amino-2-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃COOH

2: Li/NH₃ / tetrahydrofuran; 2-methyl-propan-2-ol

3: 6 N hydrochloric acid / tetrahydrofuran; H₂O / 110 °C

With hydrogenchloride; ammonia; lithium; trifluoroacetic acid; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ja00255a063

Reference yield:

: 110510-47-9
(R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester

: 64682-83-3,120346-42-1
(R)-2-phenoxy-3-phenylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: CF₃COOH

2: Li/NH₃ / tetrahydrofuran; 2-methyl-propan-2-ol

3: 6 N hydrochloric acid / tetrahydrofuran; H₂O / 110 °C

With hydrogenchloride; ammonia; lithium; trifluoroacetic acid; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ja00255a063