(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

Base Information

Chemical Name:(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate
CAS No.:343326-72-7
Molecular Formula:C₂H₂O₄*C₂₁H₃₁N₃O₂
Molecular Weight:447.532
Hs Code.:

Synonyms:(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

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Chemical Property of (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

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Technology Process of (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

There total 6 articles about (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-tert-butoxycarbonylamino-3-(2-aminophenyl)-amino-propionic acid

: 343326-72-7
(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / Reflux

2: hydrogen; acetic acid / 6 h / 20 °C

3: potassium iodide; tetrabutylammomium bromide; potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

4: hydrogenchloride; water / ethanol / 2 h / 60 °C

With hydrogenchloride; tetrabutylammomium bromide; water; hydrogen; potassium carbonate; acetic acid; potassium iodide; In ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 252209-91-9
(R)-(-)-2-oxo-3-tert-butoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine

: 343326-72-7
(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium iodide; tetrabutylammomium bromide; potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

2: hydrogenchloride; water / ethanol / 2 h / 60 °C

With hydrogenchloride; tetrabutylammomium bromide; water; potassium carbonate; potassium iodide; In ethanol; dimethyl sulfoxide;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 343326-72-7
(R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / ethanol / 4 h / Reflux

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C / Inert atmosphere

3: toluene / Reflux

4: hydrogen; acetic acid / 6 h / 20 °C

5: potassium iodide; tetrabutylammomium bromide; potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

6: hydrogenchloride; water / ethanol / 2 h / 60 °C

With hydrogenchloride; palladium 10% on activated carbon; tetrabutylammomium bromide; water; hydrogen; potassium carbonate; acetic acid; potassium iodide; In methanol; ethanol; dimethyl sulfoxide; toluene;