252209-91-9

Upstream product

• 209223-33-6 (R)-(+)-2-oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 108-94-1 cyclohexanone 
• 73259-81-1 (R)-2-tert-butoxycarbonyl-3-aminopropionic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 209223-32-5 (R)-(-)-2-tert-butoxycarbonylamino-3-(2-nitrophenylamino)propionic acid 
• 74628-31-2 N-1-cyclohexylbenzene-1,2-diamine 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 
• 6373-71-3 N-cyclohexyl-2-nitroaniline 
• 76387-70-7 (S)-3-amino-2-tert-butoxycarbonylaminopropionic acid 
• 209223-34-7 (3R)-(-)-2-oxo-3-tert-butoxycarbonylamino-5-(2-cyclohexen-1-yl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 

Downstream Products

• 209223-35-8 (R)-(-)-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 343326-72-7 (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oxalate 
• 209219-38-5 (R)-(-)-3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid 
• 209223-73-4 (R)-1-tert-butylcarbonylmethyl-2-oxo-3-tert-butoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 343326-73-8 (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-phenoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 

Relevant academic research and scientific papers

CHOLECYSTOKININ 2 RECEPTOR TARGETED NIR IMAGING AND USE THEREOF

Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.

CCK2R-DRUG CONJUGATES

The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of drugs to a mammalian recipient. Also described are methods of making and using CCK2R-drug conjuga

CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY

Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

1,5-benzodiazepine derivatives

This invention relates to 1,5-benzodiazepine derivatives, which are each represented by the following formula (1): wherein R1represents a lower alkyl group, R2and R3may be the same or different and represent a hydrogen atom or a lower alkyl group, R4represents a cyclohexyl group or phenyl group, and n stands for an integer of from 1 to 3, and also to medicines containing the same. These compounds are useful as curatives or preventives for diseases in which a gastrin receptor and/or a CCK-B receptor takes part.