(+/-)-N-1-acetyl-1-phenyl-2-propenylamine

Base Information

• Chemical Name: (+/-)-N-1-acetyl-1-phenyl-2-propenylamine
• CAS No.: 154614-38-7
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 154614-38-7.mol

Synonyms:(+/-)-N-1-acetyl-1-phenyl-2-propenylamine

Chemical Property of (+/-)-N-1-acetyl-1-phenyl-2-propenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-1-acetyl-1-phenyl-2-propenylamine

There total 8 articles about (+/-)-N-1-acetyl-1-phenyl-2-propenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(α-phenylpropargyl)acetamide (123772-66-7) → (+/-)-N-1-acetyl-1-phenyl-2-propenylamine (154614-38-7)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethylenediamine; N,N-dimethyl-formamide; at 20 ℃; for 3h; under 760 Torr;

DOI:10.1016/j.tetasy.2004.01.035

Reference yield: 81.0%

allylbenzene (300-57-2,57807-91-7) + 3-methyl-5H-1,4,2-dioxazol-5-one → (+/-)-N-1-acetyl-1-phenyl-2-propenylamine (154614-38-7)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium acetate; silver(I) triflimide; In 1,2-dichloro-ethane; at 35 ℃; for 20h; regioselective reaction;

DOI:10.1021/jacs.9b00237

Reference yield: 45.0%

Isopropyl acetate (108-21-4) + N-<1-(1-phenylprop-2-enyl)> trichloroacetamide (59874-90-7) → (+/-)-N-1-acetyl-1-phenyl-2-propenylamine (154614-38-7) + (1S)-1-phenyl-2-propen-1-amine (244092-75-9)

Guidance literature:

N-<1-(1-phenylprop-2-enyl)> trichloroacetamide; With sodium hydroxide; In ethanol; Inert atmosphere;

Isopropyl acetate; With Candida antarctica lipase B immobilized on acrylic resin; In hexane; at 30 ℃; for 48h; enantioselective reaction; Catalytic behavior; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/ejoc.201800346

upstream raw materials:

trimethylaluminum

(2E)-3-phenyl-2-propen-1-ol

N-(α-phenylpropargyl)acetamide

O-(3-Phenyl-2-propenyl)-2,2,2-Trichlorethanimidsaeure-O-(3-phenyl-2-propenyl)ester

Downstream raw materials:

1-(phenyl)allylamine

(R)-(-)-N-acetylphenylglycine

(S)-N-acetyl-2-phenylglycine

N-[(1R)-1-phenylprop-2-en-1-yl]benzamide