3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

Base Information

Chemical Name:3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester
CAS No.:1622068-66-9
Molecular Formula:C₂₁H₂₀N₂O₅
Molecular Weight:380.4
Hs Code.:

Synonyms:3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

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Chemical Property of 3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

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Technology Process of 3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

There total 3 articles about 3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1621689-03-9
3-(3-chloro-6-oxo-6H-pyridazin-1-ylmethyl)-benzoic acid methyl ester

: 1622068-65-8
2-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-ethanol

: 1622068-66-9
3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1622068-66-9
3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;

Reference yield:

: 79906-55-1
2-(3-bromo-phenoxy)-ethanol

: 1622068-66-9
3-{3-[3-(2-hydroxy-ethoxy)-phenyl]-6-oxo-6H-pyridazin-1-ylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;