7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Base Information

Chemical Name:7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate
CAS No.:1356332-71-2
Molecular Formula:C₂₃H₂₁N₃O₄
Molecular Weight:403.437
Hs Code.:

Synonyms:7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

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Chemical Property of 7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

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Technology Process of 7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

There total 9 articles about 7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-74-5
rac-5-(tert-butoxycarbonyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine-7,8-diyl diacetate

: 1356332-71-2
7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: rac-5-(tert-butoxycarbonyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine-7,8-diyl diacetate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356332-71-2
7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3.1: dmap / tetrahydrofuran / 125 h / 20 °C

4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C / Inert atmosphere

6.1: potassium permanganate; methyl tributylammonium chloride / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere

6.2: 0 - 5 °C

7.1: pyridine / 48 h / 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With pyridine; hydrogenchloride; potassium permanganate; N-Bromosuccinimide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl tributylammonium chloride; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane;

Reference yield:

: 134-81-6
benzil

: 1356332-71-2
7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

3.1: dmap / tetrahydrofuran / 125 h / 20 °C

4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C / Inert atmosphere

6.1: potassium permanganate; methyl tributylammonium chloride / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere

6.2: 0 - 5 °C

7.1: pyridine / 48 h / 20 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With pyridine; hydrogenchloride; potassium permanganate; N-Bromosuccinimide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl tributylammonium chloride; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane;