carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester
• CAS No.: 328083-90-5
• Molecular Formula: C₁₇H₂₄F₂N₂O₂
• Molecular Weight: 326.387
• Mol file: 328083-90-5.mol

Synonyms:carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester

Chemical Property of carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester

There total 1 articles about carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) + alpha-bromo-3,4-difluorotoluene (85118-01-0) → carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester (328083-90-5)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 16h; Heating / reflux;

Reference yield:

carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester (328083-90-5) → 1-[(3,4-Difluorophenyl)methyl]-piperidin-4-ylamine dihydrochloride (328083-91-6)

Guidance literature:

With hydrogenchloride; In water; for 16h;

Reference yield:

carbamic acid, [1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-, 1,1-dimethylethyl ester (328083-90-5) → N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/acschemneuro.7b00257

upstream raw materials:

(piperidin-4-yl)carbamic acid tert-butyl ester

alpha-bromo-3,4-difluorotoluene

Downstream raw materials:

1-[(3,4-Difluorophenyl)methyl]-piperidin-4-ylamine dihydrochloride

1-(3,4-difluorobenzyl)piperidin-4-amine