Technology Process of 3-cyano-2-(4-methylphenylethynyl)pyridine
There total 3 articles about 3-cyano-2-(4-methylphenylethynyl)pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromonicotinonitrile;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium L-ascorbate; diisopropylamine;
In
tetrahydrofuran;
at 40 ℃;
for 0.5h;
Inert atmosphere;
4-n-methylphenylacetylene;
In
tetrahydrofuran;
at 40 ℃;
for 36h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 12 h / Reflux
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; sodium L-ascorbate / tetrahydrofuran / 0.5 h / 45 °C / Inert atmosphere
2.2: 120 h / 40 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus pentoxide; tetrabutylammomium bromide; sodium L-ascorbate; diisopropylamine;
In
tetrahydrofuran; toluene;
2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2015.05.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid / 12 h / Reflux
2.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 12 h / Reflux
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; sodium L-ascorbate / tetrahydrofuran / 0.5 h / 45 °C / Inert atmosphere
3.2: 120 h / 40 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus pentoxide; tetrabutylammomium bromide; acetic acid; sodium L-ascorbate; diisopropylamine;
In
tetrahydrofuran; toluene;
3.1: |Sonogashira Cross-Coupling / 3.2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2015.05.005
