5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

Base Information

Chemical Name:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester
CAS No.:1421318-29-7
Molecular Formula:C₃₉H₃₀N₆O₆
Molecular Weight:678.704
Hs Code.:

Synonyms:5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

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Chemical Property of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

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Technology Process of 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

There total 9 articles about 5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1421318-25-3
(3-pyren-1-yl-prop-2-ynyloxy)acetic acid

: C₁₈H₁₈N₆O₄

: 1421318-29-7
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 20h;
DOI:10.1039/c3cc38251f

Reference yield:

: 1421318-26-4
5-(4-azidobenzoylamino)isophthalic acid dimethyl ester

: 1421318-29-7
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 3 h / 50 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

2.2: 48 h / 40 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f

Reference yield:

: 99-27-4
dimethyl 5-aminoisophthalate

: 1421318-29-7
5-(4-azidobenzoylamino)-N-{2-[2-((3-(pyren-1-yl)prop-2-ynyl)oxy)acetylamino]-ethyl}isophthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / Reflux

2.1: sodium hydroxide / methanol / 3 h / 50 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0.08 h

3.2: 48 h / 40 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc38251f