Technology Process of 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester
There total 8 articles about 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyano-3-hydroxyphenyl)ethoxy]-5-ethylphenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 20 ℃;
for 3h;
DOI:10.1021/jm010833f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / H2; aq. HCl / Pd/C / 16 h / 20 °C
2: 29 percent / aq. NaHCO3 / diethyl ether / 48 h / 20 °C
3: 32 percent / DEAD; PPh3 / tetrahydrofuran / 16 h / 20 °C
4: 67 percent / Pd(PPh3)4; NaBH4 / tetrahydrofuran / 3 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); hydrogen; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether;
3: Mitsunobu reaction;
DOI:10.1021/jm010833f
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 29 percent / aq. NaHCO3 / diethyl ether / 48 h / 20 °C
2: 32 percent / DEAD; PPh3 / tetrahydrofuran / 16 h / 20 °C
3: 67 percent / Pd(PPh3)4; NaBH4 / tetrahydrofuran / 3 h / 20 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether;
2: Mitsunobu reaction;
DOI:10.1021/jm010833f