3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione
CAS No.:122185-82-4
Molecular Formula:C₁₄H₁₀BrFN₂O₂S
Molecular Weight:369.214
Hs Code.:

Synonyms:3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

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Technology Process of 3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43088-42-2
2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 112734-22-2
4-bromo-2-fluorobenzylamine

: 503-38-8
trichloromethyl chloroformate

: 122185-82-4
3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With sodium methylate; In 1,4-dioxane; diethyl ether; ethanol; hexane; water;

Reference yield:

: 1028278-92-3
2-[3-(4-Bromo-2-fluoro-benzyl)-ureido]-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 122185-82-4
3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With sodium methylate; In methanol; for 2h; Yield given; Heating;
DOI:10.1016/0223-5234(93)90112-R

Reference yield:

: 43088-42-2
2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 122185-82-4
3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dioxane, RT, 1 h, 2.) dioxane, RT, 12 h

2: CH₃ONa / methanol / 2 h / Heating

With sodium methylate; In methanol;
DOI:10.1016/0223-5234(93)90112-R