Technology Process of methyl trans-3,4-diphenyl-1-<5-<(tert-butyldimethylsilyl)oxy>pentyl>cyclopentanecarboxylate
There total 11 articles about methyl trans-3,4-diphenyl-1-<5-<(tert-butyldimethylsilyl)oxy>pentyl>cyclopentanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium / diethyl ether / 3 h / Heating
2: 20percent HBr / aq. ethanol / Heating
3: 92 percent / Zn dust, TiCl4 / tetrahydrofuran / 2.5 h / Ambient temperature
4: 1.) BH3*THF, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, 0 deg C to room temperature, 2.) room temperature, 1 h
5: 95 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.33 h / -60 °C
6: Br2, sodium bicarbonate buffer / H2O
7: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 30 min, 2.) -60 to -15 deg C
With
sodium hydroxide; n-butyllithium; borane-THF; oxalyl dichloride; sodium bicarbonate buffer; hydrogen bromide; dihydrogen peroxide; bromine; sodium; titanium tetrachloride; dimethyl sulfoxide; diisopropylamine; zinc;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00294a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / imidazole / dimethylformamide / 1 h / Ambient temperature
2: 70 percent / pyridine / 0 - 4 °C
3: NaI / acetone / 5 h / Ambient temperature
4: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 30 min, 2.) -60 to -15 deg C
With
pyridine; 1H-imidazole; n-butyllithium; diisopropylamine; sodium iodide;
In
N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00294a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 20percent HBr / aq. ethanol / Heating
2: 92 percent / Zn dust, TiCl4 / tetrahydrofuran / 2.5 h / Ambient temperature
3: 1.) BH3*THF, 2.) 3 N NaOH, 30percent H2O2 / 1.) THF, 0 deg C to room temperature, 2.) room temperature, 1 h
4: 95 percent / oxalyl chloride, DMSO / CH2Cl2 / 0.33 h / -60 °C
5: Br2, sodium bicarbonate buffer / H2O
6: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 30 min, 2.) -60 to -15 deg C
With
sodium hydroxide; n-butyllithium; borane-THF; oxalyl dichloride; sodium bicarbonate buffer; hydrogen bromide; dihydrogen peroxide; bromine; titanium tetrachloride; dimethyl sulfoxide; diisopropylamine; zinc;
In
tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo00294a016
