3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

Base Information

Chemical Name:3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide
CAS No.:1042927-02-5
Molecular Formula:C₃₆H₄₄N₄O₇S
Molecular Weight:676.834
Hs Code.:

Synonyms:3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

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Chemical Property of 3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

Chemical Property:

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Technology Process of 3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

There total 1 articles about 3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1042927-01-4
3-bromophenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)piperidide

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1042927-02-5
3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In toluene; Reflux;
DOI:10.1016/j.bmcl.2008.11.019

Reference yield:

: 1042927-02-5
3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

: 108-24-7
acetic anhydride

: 1042927-04-7
3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-acetyl hydroxyamidine)-4-(2-Boc-amidoethyl)piperidide

Guidance literature:: 3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide; With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 4h;

acetic anhydride; With acetic acid; In ethanol;

Reference yield:

: 1042927-02-5
3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide

: C₃₆H₄₇N₅O₇S

Guidance literature:: 3-(3,4-dimethoxyphenyl)phenyl sulfonyl-d/l-Phe(3-CN)-4-(2-Boc-amidoethyl)-piperidide; With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; for 4h; Reflux;

With acetic anhydride; acetic acid; at 20 ℃; for 0.5h;

With palladium on activated charcoal; hydrogen; acetic acid; In water; at 30 ℃;
DOI:10.1016/j.bmcl.2008.11.019