4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide

Base Information

• Chemical Name: 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide
• CAS No.: 223500-36-5
• Molecular Formula: C₂₁H₂₃FN₄O₂
• Molecular Weight: 382.438

Synonyms:4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide

Chemical Property of 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide

Chemical Property:

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Technology Process of 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide

There total 6 articles about 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Propyl isocyanate (110-78-1) + N-[4-(7-fluoro-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide (223500-33-2) → 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide (223500-36-5)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0960-894X(99)00044-X

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide (223500-36-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / TMEDA, nBuLi / tetrahydrofuran

2: 22 percent / H₂NNH₂*2HCl / methanol; H₂O

3: 85 percent / CHCl₃

4: 74 percent / tetrahydrofuran

5: 63 percent / CH₂Cl₂

With n-butyllithium; hydrazine dihydrochloride; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;

DOI:10.1016/S0960-894X(99)00044-X

Reference yield:

4-(Benzhydrylidene-amino)-N-methoxy-N-methyl-benzamide → 4-(4-acetylamino-phenyl)-6-fluoro-1-methyl-1H-phthalazine-2-carboxylic acid propylamide (223500-36-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / TMEDA, nBuLi / tetrahydrofuran

2: 22 percent / H₂NNH₂*2HCl / methanol; H₂O

3: 85 percent / CHCl₃

4: 74 percent / tetrahydrofuran

5: 63 percent / CH₂Cl₂

With n-butyllithium; hydrazine dihydrochloride; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;

DOI:10.1016/S0960-894X(99)00044-X

upstream raw materials:

Propyl isocyanate

N-[4-(7-fluoro-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide

4-fluorobenzaldehyde

4-(7-fluoro-phthalazin-1-yl)-phenylamine

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